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DeCS
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Descriptor English:
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Oncogene Proteins v-erbA
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Descriptor Spanish:
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Proteínas Oncogénicas v-erbA
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Descriptor Portuguese:
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Proteínas Oncogênicas v-erbA
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Synonyms English:
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erbA Oncogene Proteins
v-erbA Proteins
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Tree Number:
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D12.776.624.664.520.750.882
D12.776.964.700.750.882
D12.776.964.775.750.882
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Definition English:
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Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation. |
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Indexing Annotation English:
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IM; coord with specific virus (IM); /drug eff /ultrastruct permitted; DF: note short X ref
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History Note English:
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95; was ONCOGENE PROTEIN ERBA (NM) 1987-94
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Allowable Qualifiers English:
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Record Number:
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32106
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Unique Identifier:
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D018774
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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